Jeff Davis told Zap2it that the two shows are "nothing alike" and accused the CW vampire series of being "high camp".
"Even though there's a ton of comparisons, like that our look and feel seems like Vampire Diaries or Twilight, they're nothing alike actually," he argued.
The showrunner revealed that he had used 1987 film The Lost Boys as a "template".
"When I actually first talked to MTV about this... they asked me if I was interested in doing Teen Wolf and I asked them how they planned on doing it, because the original movie is a comedy," he explained.
"[This new version is] funny, sexy, romantic [and] scary. To me it's much more in the vein of The Lost Boys or even Buffy without the high camp [of] Vampire Diaries."
Davis previously claimed that much of the series is inspired by Buffy and Spider-Man comics.
Teen Wolf premiered last night on MTV and continues tonight at 10/9c.
> Teen Wolf 'stands out through sense of humour'
Watch a trailer for Teen Wolf below: