Cherry refused to say which of the cast members he was talking about but claimed that he has to coach the actress to perform her lines well.
Cherry made the comments at a Producers Guild conference, The Hollywood Reporter says.
"One of my actresses on Desperate Housewives is not funny," he said. "[I tell her,] 'Sweetie, if you raise your eyebrow here, you'll get a laugh'. She does, and she gets nominations. Daddy's little girl does comedy. I'm part daddy, part psychiatrist."
Cherry, who has been the centre of controversy before, is currently embroiled in a lawsuit with former Housewives star Nicolette Sheridan, who is suing for wrongful termination, battery and unlawful retaliation.
In documents relating to the lawsuit, Sheridan has claimed that Cherry described her former co-star Eva Longoria as "a girl with no t*ts that looks like a boy" and alleged that he said: "I hope [Sheridan's former co-star] Teri Hatcher gets hit by a car and dies."
The case is due to go to court on June 8.